From I-95: Take exit 93 (Perryville/Port Deposit). Turn Right onto MD-275/Perrylawn Dr and follow for 2.8 miles. Turn Right on MD-276/Jacob Tome Memorial Highway. The Old South Smoke House is 3/4 of a mile on the left.
From Route 1: Take Route 1 and turn on MD-276/Jacob Tome Memorial Highway. The Old South Smoke House is 5 miles ahead on the right.